Neuroscience research at the Sagol Department of Neurobiology of the University of Haifa is a unique enterprise, focusing on the interface between behavior and its neural substrates.
Each of our research groups, ranging across diverse neuroscience disciplines and model systems, focuses on particular behaviors and seek to unveil their underlying mechanisms. These explorations are conducted on multiple levels, from the molecular and cellular mechanisms to the study of whole neuronal systems.
The methods employed by our faculty include molecular and cellular biology, genetic manipulations, microscopy, in-vitro and in-vivo electrophysiology and human functional imaging. Together, we illuminate topics in learning and memory, and cognitive processes in health and disease from diverse angles, ultimately aiming at understanding the neuronal processes yielding complex behaviors.
Taha, E., Patil, S.,... Rosenblum, K, (2020).eEF2/eEF2K Pathway in the Mature Dentate Gyrus Determines Neurogenesis Level and Cognition.Current Biology.
Richter-Levin G, Stork O, Schmidt MV. (2019). Animal model of PTSD: a challenge to be met. Mol. Psychiatry. 2019 24:1135-1156. doi: 10.1038/s41380-018-0272-5.
Ardi Z, Richter-Levin A, Xu L, Cao X, Volkmer H, Stork O, Richter-Levin G. The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience. Sci Rep. 2019 9:13513. doi: 10.1038/s41598-019-49824-4.
Gould, N. L., Elkobi, A., Edry, E., Daume, J., & Rosenblum, K. (2020). Muscarinic-Dependent miR-182 and QR2 Expression Regulation in the Anterior Insula Enables Novel Taste Learning. Eneuro.
Koltun, B., Ironi, S., Gershoni-Emek, N., Barrera, I., Hleihil, M., Nanguneri, S., ... & Rosenblum, K. (2020). Measuring mRNA translation in neuronal processes and somata by tRNA-FRET. Nucleic acids research, 48(6), e32-e32.
Rayi, P. R., Koyavski, L., Chakraborty, D., Bagrov, A., & Kaphzan, H. (2019). α1-Na/K-ATPase inhibition rescues aberrant dendritic calcium dynamics and memory deficits in the hippocampus of an Angelman syndrome mouse model. Progress in neurobiology, 182, 101676.
Koyavski, L., Panov, J., Simchi, L., Rayi, P. R., Sharvit, L., Feuermann, Y., & Kaphzan, H. (2019). Sex-Dependent Sensory Phenotypes and Related Transcriptomic Expression Profiles Are Differentially Affected by Angelman Syndrome. Molecular neurobiology, 56(9), 5998-6016.
Kfir, A., Awasthi, R., Ghosh, S., Kundu, S., Paul, B., Lamprecht, R., & Barkai, E. (2020). A cellular Mechanism of Learning-induced enhancement of Synaptic inhibition: pKc-Dependent Upregulation of KCC2 Activation. Scientific Reports, 10(1), 1-11.
Chandra, N., Awasthi, R., Ozdogan, T., Johenning, F. W., Imbrosci, B., Morris, G., ... & Barkai, E. (2019). A cellular mechanism underlying enhanced capability for complex olfactory discrimination learning. ENeuro, 6(1).
Stern, S., Sarkar, A., Stern, T., Mei, A., Mendes, A. P., Stern, Y., ... & Kim, Y. (2019). Mechanisms Underlying the Hyperexcitability of CA3 and Dentate Gyrus Hippocampal Neurons Derived From Patients With Bipolar Disorder. Biological psychiatry.
